St. Louis Park Chiropractor Best Practices

Research Commentary;

Exercise to Decrease Cancer Risk

A review of

Orange, Samuel T., et al. “Acute aerobic exercise‐conditioned serum reduces colon cancer cell proliferation in vitro through interleukin‐6‐induced regulation of DNA damage.” International Journal of Cancer 151.2 (2022): 265-274.

Reviewed By Dr. Bryan Stephens

Exercise to Decrease Cancer Risk

Summarized Review Conclusions

Exercise has been long associated with decreased risk of colon cancer.  The focus of this article was to evaluate the mechanism of how it assists with lowering cancer cell proliferation.  By exposing the cancer cells to serum from participants post-exercise vs pre-exercise along with a non-exercise control group, they were able to evaluate the changes.  They found that the serum from the post-exercise group inhibited the growth of colon cancer cells.  They went on to propose the difference came from an increase of interleukin 6 in the blood serum leading to an improved regulation of DNA damage and repair.

“Our results show that acute aerobic exercise-conditioned serum reduced colon cancer cell proliferation in vitro. This was accompanied by decreased levels of intracellular γ-H2AX, indicating a reduction in DNA damage.”

Orange, Samuel T., et al. “Acute aerobic exercise‐conditioned serum reduces colon cancer cell proliferation in vitro through interleukin‐6‐induced regulation of DNA damage.” International Journal of Cancer 151.2 (2022): 265-274.

“…exercise-conditioned  serum  reduced  cell proliferation compared to control”

Orange, Samuel T., et al. “Acute aerobic exercise‐conditioned serum reduces colon cancer cell proliferation in vitro through interleukin‐6‐induced regulation of DNA damage.” International Journal of Cancer 151.2 (2022): 265-274.

Introduction to the Research

Physical activity has been associated with a reduction in colon cancer rates and can help protect against it.  The authors looked at some of the previous mechanisms in how it achieved this.  They mentioned that past studies focused on how physical activity helps with reducing fat, circulating insulin, and proinflammatory cytokines.  They took it a step further when looking at how physical activity affected the colon cancer rates when independent of reduction of fat.  This becomes key when you look at the simplicity of getting out and exercising to reduce chances of cancer.

Research Methodology

“Our study used a two-site, prospective, randomised controlled, crossover design. Participants completed an acute bout of moderate-intensity aerobic interval exercise and a nonexercise control experiment in a randomised, counterbalanced order, separated by 2 to7 days (median: 6 days). The randomisation sequence was stratified by site and generated in block sizes of four by an independent researcher using online randomisation software. The order was concealed from the research team using opaque, sealed envelopes until eligibility was confirmed. Before visiting the laboratory, participants were instructed to eat the same meal 2 to 5 hours prior, not to engage in moderate- to vigorous-intensity physical activity or consume alcohol for≥24 hours, avoid caffeine intake for≥12 hours, and to arrive fully hydrated.”

Orange, Samuel T., et al. “Acute aerobic exercise‐conditioned serum reduces colon cancer cell proliferation in vitro through interleukin‐6‐induced regulation of DNA damage.” International Journal of Cancer 151.2 (2022): 265-274.

Blood samples were taken from the participants in the non exercise control group as well as exercise group both pre and post workout.  Cancer cells were then exposed to the blood serum samples taken and the results were gathered.

Research Findings

“We incubated LoVo cells for 48 hours with medium containing 10%human serum collected before and after the acute exercise bout and a nonexercise control experiment. Stimulating LoVo cells with post-exercise serum decreased cell proliferation compared to pre exercise serum ( 4.2%, 95% CI 6.8 to 1.5%;P=.006; Figure1A), whereas postcontrol serum led to an increase in cell proliferation compared to precontrol serum (5.4%, 95% CI 2.2 to 8.6%;P=.003). After control-ling  for  prevalues,  exercise-conditioned  serum  reduced  cell proliferation compared to control ( 5.7%, 95% CI 8.8 to 2.6%;P=.002”

Orange, Samuel T., et al. “Acute aerobic exercise‐conditioned serum reduces colon cancer cell proliferation in vitro through interleukin‐6‐induced regulation of DNA damage.” International Journal of Cancer 151.2 (2022): 265-274.

Research References

As always with these reviews, these are my takeaways from the article and I encourage you to read the article in its entirety.  The references used in this article by the authors of this article are listed here.

Our Message

When you are looking for a Chiropractor near you that you can trust, choose one who will not only get rid of your back pain, neck pain, or headaches but who will also guide you to living a healthier lifestyle to keep you out of pain. Our St. Louis Park Chiropractors located in the West End, near the corner of MN-100 S & Lake Rd./Westside Dr., are here to teach you that taking care of your mental health and getting the proper nutrients are just as important as the chiropractic adjustment to stay healthy, lower inflammation and limit pain.