St. Louis Park Chiropractor Best Practices Research Commentary;

Probiotics for Gut Health

A review of
Mazziotta C, Tognon M, Martini F, Torreggiani E, Rotondo JC. Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health. Cells. 2023 Jan 2;12(1):184. doi: 10.3390/cells12010184. PMID: 36611977; PMCID: PMC9818925.
Reviewed By Dr. Erik Waldeland

Probiotics for Gut Health
Summarized Review Conclusions

Probiotics, through their interaction with intestinal immune cells, play a crucial role in enhancing host immune homeostasis and function. While the molecular mechanisms underlying their immunomodulatory functions are not fully elucidated, existing evidence suggests that probiotics activate both innate and adaptive immune responses in the intestine. This activation involves the production of cytokines and chemokines from various immune cells, as well as the stimulation of IgA-producing cells and subsequent IgA secretion. Consequently, probiotics contribute to the improvement of the host immune system, thereby preventing and managing immune-related diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), inflammation, diarrhea, pathogenic infections, infant colic, and certain types of cancer.

“Various classes of intestinal immune cells play an important role in the host immune functions to counteract infections, and regulate the immune tolerance to commensal bacteria and ingested antigens.”

“Given its cytological composition and its histological architecture, the intestine is considered the largest immunological organ as it contains approximately 70–80% of all IgA-producing B cells”

Introduction to the Research

The intestine is a complex and dynamic ecosystem which has evolved specific immune cellular characteristics over time because of incessant exposure to numerous antigens and pathogenic agents [1]. Various classes of intestinal immune cells play an important role in the host immune functions to counteract infections and regulate the immune tolerance to commensal bacteria and ingested antigens. However, immune cell functions and activities can be modulated to a large degree by the intestinal commensal microbes with health-promoting and beneficial immunomodulatory properties [2]. Indeed, immune cells, commensal microorganisms and nutrients constantly interact with and react to one another in a stable environment in order to maintain immune homeostasis and modulate both innate and adaptive immune responses [3]. This interaction improves the functions of the immune system.

Research Methodology

This research review examined various methods of research from randomized control trials to other research reviews looking at the effects probiotics have on the immune function as well as looking specifically at different systems of the body and how the interactions can have various benefits for all systems through providing the gut with good bacteria.  The article examined over 200 research articles and summarized the findings.

Research Findings 

The intestinal microbiota plays essential immunomodulatory activities, which can occur both locally and systemically. A complex biochemical signaling takes place between the gastrointestinal tract and different systems of the body, such as the central nervous and respiratory systems. The role of the gut microbiota in this interplay is defined as microbiota–gut–brain and microbiota–gut–lung axes. While the commensal bacteria carry out their functions/activities in the gut, they are able to act distally in other anatomical districts, such as brain and lungs. Modifications in the microbiome which can be induced by an altered homeostasis, specific conditions and/or dietary modifications, might alter the immune function and homeostasis in the central nervous system and respiratory tract.

Probiotics, through their interaction with intestinal immune cells, play a crucial role in enhancing host immune homeostasis and function. While the molecular mechanisms underlying their immunomodulatory functions are not fully elucidated, existing evidence suggests that probiotics activate both innate and adaptive immune responses in the intestine. This activation involves the production of cytokines and chemokines from various immune cells, as well as the stimulation of IgA-producing cells and subsequent IgA secretion. Consequently, probiotics contribute to the improvement of the host immune system, thereby preventing and managing immune-related diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), inflammation, diarrhea, pathogenic infections, infant colic, and certain types of cancer.

Reference

As always with these reviews, these are my takeaways from the article and I encourage you to read the article in its entirety.  The references used in this article by the authors of this article are listed here.

Our Message

When you are looking for a Chiropractor near you that you can trust, choose one who will not only get rid of your back pain, neck pain, or headaches but who will also guide you to living a healthier lifestyle to keep you out of pain. Our St. Louis Park Chiropractors located in the West End, near the corner of MN-100 S & Lake Rd./Westside Dr., are here to teach you that taking care of your mental health and getting the proper nutrients are just as important as the chiropractic adjustment to stay healthy, lower inflammation and limit pain.